| 1 | Lithia Motors, Inc. | $11.8B | -- | 80 |
| 2 | hallmark health system - lawrence memorial hospital campus | $500.7M | 3,000 | 70 |
| 3 | tufts university department of biology | $343.3M | 3,000 | 70 |
| 4 | DAIRY QUEEN | $86.3M | 350 | 60 |
| 5 | Guldmann North America | $85.6M | 350 | 60 |
| 6 | VRC Insurance Systems | $83.4M | 125 | 60 |
| 7 | Urban Pharms | $76.6M | 350 | 60 |
| 8 | Halo Collective Inc. | $76.6M | 350 | 60 |
| 9 | Jantek Industries LLC #Jantekwindows | $74.0M | 125 | 60 |
| 10 | The First Marblehead Corporation | $73.6M | 350 | 60 |
| 11 | Filtrscience | $66.5M | 350 | 60 |
| 12 | mirabella at south waterfront dba mirabella portland | $58.4M | 350 | 60 |
| 13 | Penn Fabricators | Northeast Quartz | $51.5M | 125 | 60 |
| 14 | AIRPORT CHEVROLET, INC. | $51.0M | 125 | 60 |
| 15 | Harry & David Operations Corp. | $51.0M | 125 | 60 |
| 16 | Airport Chevrolet Buick GMC Cadillac | $51.0M | 125 | 60 |
| 17 | SRC Vision | $45.0M | 125 | 60 |
| 18 | Inkbit | $45.0M | 125 | 60 |
| 19 | Tufts Dining | $40.1M | 350 | 60 |
| 20 | southern oregon esd school district | $40.1M | 350 | 60 |
| 21 | JACKSON, COUNTY OR | $34.3M | 125 | 60 |
| 22 | M C S I | $33.1M | 350 | 60 |
| 23 | riders domain | $32.5M | 350 | 60 |
| 24 | jantek industries llc | $32.4M | 125 | 60 |
| 25 | Bobcat of New York City & Long Island | $29.2M | 125 | 60 |
| 26 | Earth Breeze | $27.4M | 125 | 60 |
| 27 | Fletcher Social Investment Group (FSIG) | $26.3M | 125 | 60 |
| 28 | Eneflux Armtek Magnetics, Inc. (EA Magnetics) | $25.0M | 125 | 60 |
| 29 | montvale plaza/marty's caterers | $24.9M | 125 | 60 |
| 30 | Medford Cooperative, Inc. | $23.8M | 350 | 60 |
| 31 | Joseph's Transportation | $22.5M | 125 | 60 |
| 32 | High Tech Center | $21.3M | 125 | 60 |
| 33 | Accardi Foods, Inc. | $21.3M | 125 | 60 |
| 34 | Tufts JumboCode | $21.3M | 125 | 60 |
| 35 | spectrum orthotics and prosthetics inc. | $20.9M | 125 | 60 |
| 36 | INN AT THE COMMONS LLC | $20.5M | 125 | 60 |
| 37 | MF Reynolds, Inc. | $18.9M | 125 | 60 |
| 38 | Tufts Health Plan – Network Health | $18.9M | 350 | 60 |
| 39 | Ashley (Medford, Oregon) | $15.9M | 125 | 60 |
| 40 | Decibels Inc | $14.6M | 125 | 60 |
| 41 | Frasco, Inc | $14.4M | 125 | 60 |
| 42 | AIC Companies LLC | $14.4M | 125 | 60 |
| 43 | The Fletcher School at Tufts University | $14.3M | 125 | 60 |
| 44 | Vocational Education | $14.3M | 125 | 60 |
| 45 | Tufts University Debate Society | $14.3M | 125 | 60 |
| 46 | Tufts University Gordon Institute | $14.3M | 125 | 60 |
| 47 | Tufts Women in Computer Science (WiCS) | $14.3M | 125 | 60 |
| 48 | Tufts Computer Science Exchange | $14.3M | 125 | 60 |
| 49 | E.U.R.O. TECH. CORP. | $13.3M | -- | 75 |
| 50 | Silk Therapeutics, Inc. | $13.0M | 125 | 60 |
| 51 | ASSP Southern Oregon Chapter | $12.6M | 125 | 60 |
| 52 | Action Rider Tack | $12.4M | 125 | 60 |
| 53 | forget me not faces | $12.4M | 30 | 60 |
| 54 | Siskiyou Sports | $12.4M | 30 | 60 |
| 55 | joya distributing | $12.4M | 30 | 60 |
| 56 | Wire Markers Plus | $12.4M | 30 | 60 |
| 57 | Goodwill of Southern Oregon | $12.2M | 30 | 60 |
| 58 | Sentry Ford and Lincoln | $12.2M | 30 | 60 |
| 59 | Green Leaf Kratom | $12.2M | 30 | 60 |
| 60 | The Woolly Sheep Mountain Trading Corp. | $12.2M | 30 | 60 |
| 61 | Zales Jewerly | $12.2M | 30 | 60 |
| 62 | LAURASTAR US - Joya Distributing, Inc. | $12.2M | 30 | 60 |
| 63 | JRA Cycles | $12.2M | 30 | 60 |
| 64 | Lakes Appliance & TV INC | $12.2M | 30 | 60 |
| 65 | 711 Store | $12.2M | 30 | 60 |
| 66 | Beds For Less | $12.2M | 30 | 60 |
| 67 | Ashland General Hardware | $12.2M | 30 | 60 |
| 68 | Action Heavy Haul, LLC. | $12.2M | 30 | 60 |
| 69 | metromatic manufacturing compa | $12.2M | 125 | 60 |
| 70 | Petesgourmet | $12.2M | 30 | 60 |
| 71 | arthurs pastry shop | $12.2M | 30 | 60 |
| 72 | Wake-N-Bagel | $12.2M | 30 | 60 |
| 73 | ahuva bagels | $12.2M | 30 | 60 |
| 74 | casa de pao | $12.2M | 30 | 60 |
| 75 | le rosellis food specialties i | $12.2M | 30 | 60 |
| 76 | Imperial Masonry Inc | $11.8M | 30 | 60 |
| 77 | Focus1 Insurance | $11.0M | 30 | 60 |
| 78 | Ltc Global Solutions | $11.0M | 30 | 60 |
| 79 | Regency Blue Cross Blue Shield of Oregon | $11.0M | 30 | 60 |
| 80 | Meyer Insurance Agency, Inc. | $11.0M | 30 | 60 |
| 81 | Risman Insurance Agencies | $11.0M | 30 | 60 |
| 82 | Redwoods Leavitt Insurance Agency | $11.0M | 30 | 60 |
| 83 | Protectors Insurance LLC | $11.0M | 30 | 60 |
| 84 | Oath Cannabis & Hemp Insurance | $11.0M | 30 | 60 |
| 85 | Cecil N. Marchionne Insurance Agency, Inc. | $11.0M | 30 | 60 |
| 86 | Spectrum Benefit Solutions of Central WI LLC | $11.0M | 30 | 60 |
| 87 | aspirus medford hospital & clinics | $9.4M | 750 | 50 |
| 88 | Oregon Power | $9.4M | 30 | 50 |
| 89 | Rogue Waste, Inc | $9.3M | 125 | 50 |
| 90 | Colonial Volkswagen | $9.2M | 30 | 50 |
| 91 | Old Age Home | $8.5M | 125 | 50 |
| 92 | Get Moving USA Moving & Storage | $8.2M | 30 | 50 |
| 93 | B2B Transportation | $8.2M | 30 | 50 |
| 94 | Ace Courier Express | $8.2M | 30 | 50 |
| 95 | Boston Private Limo | $8.2M | 30 | 50 |
| 96 | Loan Processing Inc | $8.2M | 125 | 50 |
| 97 | weichert realtors-medford,n.j. | $8.2M | 125 | 50 |
| 98 | john l. scott southern oregon | $8.2M | 125 | 50 |
| 99 | Siskiyou Cascade | $8.2M | 125 | 50 |
| 100 | ABMC Janitorial Services | $7.8M | 125 | 50 |