| 1 | MAGISTR SIA | €479.2M | 350 | 70 |
| 2 | Tirdzniecības un izklaides centrs "DITTON" | €142.8M | 350 | 70 |
| 3 | Ditton Driving Chain Factory JSC | €81.9M | 350 | 60 |
| 4 | BM Industrial | €74.0M | 125 | 60 |
| 5 | Daugavpils Locomotive Repair Plant
manufacture of railway locomotives and rolling sto | €59.0M | 92 | 77 |
| 6 | Pulsar Optics
Manufacture of optical instruments and photographi | €58.8M | 131 | 77 |
| 7 | Daugavpils reģionālā slimnīca
hospitals and rehabilitation | €58.2M | 1,672 | 60 |
| 8 | Euro Energo Company
Wholesale of solid, liquid and gaseous fuels and r | €57.0M | 26 | 77 |
| 9 | Intergaz
Wholesale of solid, liquid and gaseous fuels and r | €55.3M | -- | 60 |
| 10 | Latvijas Maiznieks
wholesale on a fee or contract basis | €53.6M | -- | 60 |
| 11 | SIA "AXON CABLE" | €40.7M | 643 | -- |
| 12 | SIA Intergaz | €39.2M | 125 | 60 |
| 13 | SIA "Daugavpils psihoneiroloģiskā slimnīca" | €27.3M | 1,022 | -- |
| 14 | Daugavpils psychiatric hospital
activity of hospitals | €25.1M | 978 | 77 |
| 15 | JSC Daugavpils Lokomotivju Remonta Rupnica | €24.6M | 81 | 57 |
| 16 | "Nexis Fibers" SIA | €22.3M | 133 | 60 |
| 17 | Daugavpils siltumtīkli | €21.5M | 217 | -- |
| 18 | Telestrider | €21.3M | 125 | 60 |
| 19 | Nexis Fibers
weaving of textiles | €20.6M | 117 | 77 |
| 20 | SMD Baltic
manufacture of loaded electronic boards | €19.4M | 149 | 77 |
| 21 | Ingrid A
Wholesale of solid, liquid and gaseous fuels and r | €19.3M | 57 | 77 |
| 22 | Latgales piens
Operation of dairies and cheese making | €19.3M | 150 | 77 |
| 23 | STARS MET | €18.9M | 125 | 60 |
| 24 | Eko Iso | €17.8M | 30 | 60 |
| 25 | LokRem
manufacture of railway locomotives and rolling sto | €16.4M | 306 | 77 |
| 26 | Belmast
manufacture of metal structures and parts of struc | €14.9M | 114 | 77 |
| 27 | DAUTKOM TV | €14.6M | 125 | 60 |
| 28 | Regula Baltija, SIA | €13.2M | 116 | 57 |
| 29 | "Black Mammut", Ltd. | €13.0M | 125 | 60 |
| 30 | Daugavpils dzelzsbetons
manufacture of ready-mixed concrete | €11.9M | 158 | 77 |
| 31 | Baltic HPC Association | €11.8M | 125 | 60 |
| 32 | SIA "ELLI V" | €11.3M | 117 | -- |
| 33 | Sabiedrība ar ierobežotu atbildību Intergaz Trade | €10.2M | 3 | 57 |
| 34 | SIA "Latgales Ceļdaris" | €8.8M | 65 | -- |
| 35 | SIA Savitra | €8.4M | 63 | -- |
| 36 | Allumen Production | €8.0M | 30 | 50 |
| 37 | SIA "Daugavpils ūdens" | €8.0M | 255 | -- |
| 38 | SIA "Baltijas Energomontāža" | €7.9M | 49 | -- |
| 39 | SIA "4.vara" | €7.6M | 9 | -- |
| 40 | SIA "MIX OIL" | €7.0M | 7 | -- |
| 41 | SIA "LOGERI" | €6.5M | 43 | -- |
| 42 | SIA "Latgales Alus D" | €6.3M | 75 | -- |
| 43 | SIA "Industrial Welding" | €6.1M | 74 | -- |
| 44 | SIA VERTEX LV | €6.1M | 6 | 57 |
| 45 | SIA "ENERGO-D" | €5.8M | 35 | -- |
| 46 | AS "DAUGAVPILS SPECIALIZĒTAIS AUTOTRANSPORTA UZŅĒMUMS" | €5.6M | 94 | -- |
| 47 | Starsmet | €5.6M | 57 | -- |
| 48 | Auto Welle | €5.0M | 20 | -- |
| 49 | SIA "DAERS" | €5.0M | 71 | -- |
| 50 | SIA "LIRT" | €4.9M | 3 | -- |
| 51 | SIA "CBF & LANDSCAPE" | €4.8M | 60 | -- |
| 52 | SIA "Adverza Germany" | €4.8M | 50 | -- |
| 53 | SIA "BalticSofa" | €4.8M | 22 | -- |
| 54 | SIA MIPEX | €4.6M | 11 | -- |
| 55 | Metmatus, SIA | €4.5M | 21 | -- |
| 56 | SIA "ONIORS D" | €4.4M | 40 | -- |
| 57 | SIA "MEAT UNION" | €4.3M | 60 | -- |
| 58 | Sabiedrība ar ierobežotu atbildību "MAGISTR" | €4.2M | 93 | 57 |
| 59 | SIA "LBM" | €4.2M | 47 | -- |
| 60 | SIA "SKINEST LATVIJA" | €4.2M | 7 | -- |
| 61 | Daugavpils Olimpiskais centrs | €4.1M | 101 | -- |
| 62 | swewall | €4.1M | 30 | 50 |
| 63 | SIA "DP - timber" | €4.0M | 13 | -- |
| 64 | SIA "BestVersion" | €3.8M | 14 | -- |
| 65 | Rem Pro
architectural activity | €3.8M | 67 | 72 |
| 66 | viss auto | €3.7M | 30 | 50 |
| 67 | SIA "APTIEKA "DZIEDNIEKS"" | €3.6M | 24 | -- |
| 68 | SIA "LATTEPS" | €3.6M | 88 | -- |
| 69 | SIA "Ziegler" | €3.6M | 196 | -- |
| 70 | Ritmika.eu | €3.5M | 30 | 50 |
| 71 | riga technical university, daugavpils branch | €3.4M | 30 | 50 |
| 72 | SIA "WOXPARTS" | €3.4M | 8 | -- |
| 73 | latgales industriālais tehnikums | €3.3M | 350 | 50 |
| 74 | Akciju sabiedrība "Ditton pievadķēžu rūpnīca" | €3.3M | 120 | 57 |
| 75 | Labiekārtošana-D | €3.3M | 91 | -- |
| 76 | Ed & Ko | €3.2M | 15 | -- |
| 77 | SIA "Prior Mere" | €3.1M | 4 | -- |
| 78 | SIA "STRUCTUM" | €3.1M | 55 | -- |
| 79 | SIA "DAUGAVPILS BOKSERU KLUBS" | €3.0M | 83 | -- |
| 80 | SIA "BUILDER INDUSTRY" | €2.9M | 9 | -- |
| 81 | Esteriol Solutions | €2.8M | 30 | 50 |
| 82 | SIA "Asat Elstone" | €2.8M | 34 | -- |
| 83 | SIA "BALTIC ELEKTROMONTĀŽA" | €2.8M | 50 | -- |
| 84 | SIA "LOREKS D" | €2.8M | 29 | -- |
| 85 | SIA "Stual" | €2.7M | 21 | -- |
| 86 | SIA "DMD Trans" | €2.5M | 31 | -- |
| 87 | SIA Specialplast | €2.5M | 48 | -- |
| 88 | SIA "X-MET" | €2.4M | 11 | -- |
| 89 | SIA "DIADENT" | €2.4M | 50 | -- |
| 90 | Daugavpils pilsētas Č.Belikči individuālais uzņēmums "VETZOOCENTRS" | €2.3M | 11 | -- |
| 91 | SIA "Latsweets" | €2.3M | 55 | -- |
| 92 | SIA "Farox Services" | €2.2M | 7 | -- |
| 93 | SIA "Pieci PA" | €2.1M | 13 | -- |
| 94 | SIA "ENERGO HELP" | €2.1M | 80 | -- |
| 95 | teleset it solutions | €2.1M | 30 | 50 |
| 96 | SIA "MAX BAKERY" | €2.1M | 57 | -- |
| 97 | Rital D | €2.1M | 28 | -- |
| 98 | SIA "Taikin Build" | €2.1M | 36 | -- |
| 99 | Daugavpils Bērnu veselības centrs | €2.1M | 104 | -- |
| 100 | SIA Pescara | €2.0M | 2 | -- |