| 1 | comdata cash management | €1.2B | 20,000 | 80 |
| 2 | région rhône-alpes | €754.7M | 7,500 | 70 |
| 3 | avi korssia immobilier by kw | €196.5M | 3,000 | 70 |
| 4 | Sirha Europain | €177.9M | 350 | 70 |
| 5 | WaxWrap | Natural Food Wrap | €142.8M | 350 | 70 |
| 6 | L'Auxiliaire Vie | €128.6M | 350 | 70 |
| 7 | Les Rendez-vous du Courtage Lyon | €128.6M | 350 | 70 |
| 8 | éco.déchets | €96.0M | 350 | 60 |
| 9 | erai | €95.8M | 125 | 60 |
| 10 | DCF-Lyon | €95.8M | 125 | 60 |
| 11 | Greening-e France | €69.3M | 350 | 60 |
| 12 | ensatt - ecole nationale superieure d'arts et techniques du théâtre | €65.0M | 350 | 60 |
| 13 | ARGML - halal certification | €63.5M | 125 | 60 |
| 14 | Franchise-Store.com | €59.6M | 350 | 60 |
| 15 | SOGEPAR Hôtels | €57.5M | 350 | 60 |
| 16 | as be-pop lyon (asbpl) | €56.7M | 350 | 60 |
| 17 | RAZEL-BEC Auvergne-Rhône-Alpes | €52.9M | 350 | 60 |
| 18 | DECARBOMILE | €51.0M | 125 | 60 |
| 19 | Alispharm by CBTW | €50.4M | 350 | 60 |
| 20 | Diot-Siaci Rhône Alpes | €45.9M | 125 | 60 |
| 21 | Dynaren Assistance | €45.9M | 125 | 60 |
| 22 | groupe vipeo | €45.9M | 125 | 60 |
| 23 | Eni France | €39.2M | 125 | 60 |
| 24 | niv- nouvelle industrie du vêtement | €38.1M | 30 | 60 |
| 25 | Handi-pacte Auvergne Rhône-Alpes | €35.2M | 350 | 60 |
| 26 | CCI LYON METROPOLE Saint-Etienne Roanne | €35.2M | 350 | 60 |
| 27 | enex pharma | €34.2M | -- | -- |
| 28 | pharmacie ollagnon - tran | €34.2M | -- | -- |
| 29 | eurobiomed france | €34.2M | -- | -- |
| 30 | laboratoires juvise pharmaceuticals sas | €34.2M | -- | -- |
| 31 | junior pharma france (jpf) | €34.2M | -- | -- |
| 32 | aguettant santé s.a. | €34.2M | -- | -- |
| 33 | biofilm pharma | €34.2M | -- | -- |
| 34 | mapi group: health research & commercialization | €34.2M | -- | -- |
| 35 | merck santé s.a.s. | €34.2M | -- | -- |
| 36 | d4care | €34.2M | -- | -- |
| 37 | registrat-mapi | €34.2M | -- | -- |
| 38 | eusa pharma france | €34.2M | -- | -- |
| 39 | merck france | €34.2M | -- | -- |
| 40 | s.s.b.t | €34.2M | -- | -- |
| 41 | jpil (junior pharma industrie lyon) | €34.2M | -- | -- |
| 42 | mabdesign formation | €34.2M | -- | -- |
| 43 | dermaheal | €34.2M | -- | -- |
| 44 | akka life sciences | €34.2M | -- | -- |
| 45 | cellixio | €34.2M | -- | -- |
| 46 | ab research (independent consulting & interim project management in market access / heor / rwe) | €34.2M | -- | -- |
| 47 | la grande pharmacie de montplaisir | €34.2M | -- | -- |
| 48 | pharmacie saxe quinet | €34.2M | -- | -- |
| 49 | coxsea pharma | €34.2M | -- | -- |
| 50 | afipral - association des fabricants de l'industrie pharmaceutique en rhône-alpes | €34.2M | -- | -- |
| 51 | centre léon bérard - officiel | €34.2M | -- | -- |
| 52 | novacap international sas | €34.2M | -- | -- |
| 53 | merial, a sanofi company | €34.2M | -- | -- |
| 54 | pharmacie bonglet-djian snc | €34.2M | -- | -- |
| 55 | association des etudiants lyonnais pharmaciens-ingénieurs (aelpi) | €34.2M | -- | -- |
| 56 | ea3738 cto, faculté médecine lyon sud | €34.2M | -- | -- |
| 57 | aguettant france | €34.2M | -- | -- |
| 58 | dendritics | €34.2M | -- | -- |
| 59 | neuronax (now axoltis pharma) | €34.2M | -- | -- |
| 60 | pharmacie barras-cottin-de rivoyre | €34.2M | -- | -- |
| 61 | merial s.a.s. | €34.2M | -- | -- |
| 62 | pharmalpa | €34.2M | -- | -- |
| 63 | pharmacie l + l | €34.2M | -- | -- |
| 64 | ever pharma (france) | €34.2M | -- | -- |
| 65 | pharmacie carre vendome | €34.2M | -- | -- |
| 66 | qbdex | €34.2M | -- | -- |
| 67 | pharmacie moncozet clement | €34.2M | -- | -- |
| 68 | pharmadiet veterinary france | €34.2M | -- | -- |
| 69 | parteurop pharma s.a.s. | €34.2M | -- | -- |
| 70 | vyac healthcare | €34.2M | -- | -- |
| 71 | medac france | €34.2M | -- | -- |
| 72 | lynapharm sa | €34.2M | -- | -- |
| 73 | opérateurs publics des mobilités lyonnaises | €33.5M | 350 | 60 |
| 74 | BNI ON LYON | €33.2M | 350 | 60 |
| 75 | Groupe Iteractii | €33.1M | 350 | 60 |
| 76 | 24h France Emploi | €30.0M | 350 | 60 |
| 77 | rotary district 1710 | €28.5M | 3,000 | 60 |
| 78 | Rénovation énergétique en France - Particuliers & Professionnels | €28.2M | 125 | 60 |
| 79 | COELIS PORTAGE SALARIAL | €26.3M | 125 | 60 |
| 80 | Banque Cantonale de Genève SA | €26.3M | 125 | 60 |
| 81 | MS69 | €26.1M | 350 | 60 |
| 82 | groupe Energie Metal | €25.0M | 125 | 60 |
| 83 | 6ème AVENUE - BMW | €24.8M | 125 | 60 |
| 84 | ADERLY / Invest in Lyon Agency | €23.0M | 30 | 60 |
| 85 | Ausvet Europe | €23.0M | 30 | 60 |
| 86 | DRACNIGHT BDE IDRAC LYON | €23.0M | 30 | 60 |
| 87 | LeaderPrintGroup | €22.9M | 125 | 60 |
| 88 | RDS-Tools Software | €21.3M | 125 | 60 |
| 89 | Ospi (Groupe PSIH et Collective Thinking) | €21.3M | 125 | 60 |
| 90 | Inova.io | €21.3M | 125 | 60 |
| 91 | Adelaïde Perrin - Établissements Sainte Marie Rhône | €20.9M | 125 | 60 |
| 92 | Tradoc Rhône-Alpes | €20.0M | 30 | 60 |
| 93 | ULIC Plomberie | €18.9M | 125 | 60 |
| 94 | ALMAR Rail | €17.8M | 30 | 60 |
| 95 | DOMINO RH Sports & Métiers | €17.7M | 350 | 60 |
| 96 | Bandai Namco Europe | €16.1M | 125 | 60 |
| 97 | kellal maintenance (vinci energies activités nucléaires) | €16.0M | 125 | 60 |
| 98 | k-net pro | €14.6M | 125 | 60 |
| 99 | Restaurants et Brasseries Bocuse - Paul Bocuse Officiel | €14.3M | 350 | 60 |
| 100 | l'ESTBB | €14.3M | 125 | 60 |