| 1 | Grünenthal GmbH | €1.3B | 4,900 | 69 |
| 2 | Trianel Gaskraftwerk Hamm GmbH & Co. KG | €515.2M | 6 | 69 |
| 3 | HEMA Holding GmbH | €390.7M | 5 | 69 |
| 4 | Aachener Printen- und Schokoladenfabrik Henry Lambertz GmbH & Co. KG | €365.6M | 406 | 69 |
| 5 | Bischöfliches Hilfswerk MISEREOR | €260.6M | 428 | 69 |
| 6 | FC-Moto GmbH & Co KG | €92.5M | 86 | 69 |
| 7 | MedX-spineconcept | €85.6M | 350 | 60 |
| 8 | duyvis wiener germany | €79.0M | 350 | 60 |
| 9 | Kindermissionswerk "Die Sternsinger" e.V. | €75.1M | 159 | 69 |
| 10 | Institute for Automotive Engineering (ika) | €69.4M | 350 | 60 |
| 11 | C3-Mobility | €69.4M | 350 | 60 |
| 12 | CoacHyfied | €66.6M | 350 | 60 |
| 13 | software & testing solutions | €66.6M | 350 | 60 |
| 14 | UPRTEK ® | Professional Spectrometers, Radiometers and Flickermeters | €66.5M | 350 | 60 |
| 15 | missio - Internationales Katholisches Missionswerk e.V. | €51.0M | 103 | 69 |
| 16 | LUBE & KRINGS GmbH | €49.0M | 125 | 60 |
| 17 | isac - institute of highway engineering aachen | €49.0M | 125 | 60 |
| 18 | indurad | €45.0M | 125 | 60 |
| 19 | fecken - kirfel | €42.9M | 350 | 60 |
| 20 | vygon germany | €42.8M | 350 | 60 |
| 21 | Corps Marko-Guestphalia Aachen | €40.1M | 350 | 60 |
| 22 | AIDPATH | €36.4M | 350 | 60 |
| 23 | ikv- institute for plastics processing in industry and craft at rwth aachen university | €36.4M | 350 | 60 |
| 24 | Aachener Tagung Wassertechnologie - ATW | €36.4M | 350 | 60 |
| 25 | Embassy of the Republic of Užupis to Aachen and among Friendly Communites | €36.4M | 350 | 60 |
| 26 | ITA Institut für Textiltechnik der RWTH Aachen University | €36.3M | 350 | 60 |
| 27 | Aachener Hochschulkurs Membranprozesse - HSK | €36.2M | 125 | 60 |
| 28 | FACTUR Billing Solutions GmbH | €33.1M | 350 | 60 |
| 29 | PV1000 - The Peoples Ventilator | €30.6M | 125 | 60 |
| 30 | Mathes Business | €29.9M | 125 | 60 |
| 31 | ladebusiness | €28.2M | 125 | 60 |
| 32 | Studierendenwerk Aachen | €25.4M | 331 | 69 |
| 33 | SUBLIME | €24.8M | 125 | 60 |
| 34 | Magritek Ltd | €23.7M | 125 | 60 |
| 35 | Elektor North America | €23.7M | 125 | 60 |
| 36 | Medienhaus Aachen GmbH | €23.1M | 350 | 60 |
| 37 | S&T Deutschland GmbH - Aachen | €21.3M | 125 | 60 |
| 38 | Aktionsbündnis Arbeitsmedizin | €18.9M | 350 | 60 |
| 39 | Sata GmbH | €17.8M | -- | 69 |
| 40 | W. Köpp GmbH & Co. KG | €17.1M | 60 | 69 |
| 41 | VnX Distribution | €16.4M | 30 | 60 |
| 42 | FISMEP - FIWARE for Smart Energy Platform | €16.0M | 125 | 60 |
| 43 | Liebe Graphic & Marketing House | €15.7M | 125 | 60 |
| 44 | StädteRegion Aachen | €14.7M | 302 | 69 |
| 45 | Corps Franconia Fribergensis zu Aachen | €14.3M | 125 | 60 |
| 46 | Corps Saxo-Montania | €14.3M | 125 | 60 |
| 47 | Corps Palaeo-Teutonia Aachen | €14.3M | 125 | 60 |
| 48 | sfb 985 "functional microgels and microgel systems" | €14.3M | 125 | 60 |
| 49 | SusChemSys 2.0 | €14.3M | 125 | 60 |
| 50 | Corps Saxonia-Berlin zu Aachen | €14.3M | 125 | 60 |
| 51 | aixigo AG | €14.2M | 2,021 | 69 |
| 52 | Bäckerei Moss GmbH | €14.2M | 6 | 69 |
| 53 | TH. WITT KÄLTEMASCHINENFABRIK GmbH | €13.2M | 115 | 69 |
| 54 | Zukunftscluster Wasserstoff | €13.0M | 125 | 60 |
| 55 | Chair for Electrochemical Energy Conversion and Storage Systems (ISEA) / RWTH Aachen University | €13.0M | 125 | 60 |
| 56 | m2p-labs gmbh i microbioreactors i now beckman coulter life sciences | €13.0M | 125 | 60 |
| 57 | SCHLENTER shearing blades | €13.0M | 125 | 60 |
| 58 | elexon GmbH | €12.5M | 30 | 60 |
| 59 | wiveo | €11.9M | 125 | 60 |
| 60 | Klafka&Hinz Energie-Informations-Systeme GmbH | €11.8M | 125 | 60 |
| 61 | oculavis | €11.8M | 125 | 60 |
| 62 | OSTHUS - A PharmaLex Company | €11.8M | 125 | 60 |
| 63 | LYDIA Voice Solutions | €11.8M | 125 | 60 |
| 64 | Thinking Networks AG (QVANTUM Software-as-a-Service) | €11.1M | 125 | 60 |
| 65 | xtonomy | €10.8M | 30 | 60 |
| 66 | United Manufacturing Hub | €10.8M | 30 | 60 |
| 67 | µmoon | €9.9M | 30 | 50 |
| 68 | Taeter Aachen | €8.0M | 129 | 65 |
| 69 | Institute of Mining Engineering I (BBK I) @ RWTH Aachen University | €8.0M | 30 | 50 |
| 70 | Aachener Gießerei-Familie e.V. (AGIFA) | €8.0M | 30 | 50 |
| 71 | Killian CNC Technik GmbH | €8.0M | 30 | 50 |
| 72 | Tilke GmbH & Co. KG | €7.7M | 79 | 69 |
| 73 | mecora Medizintechnik | €7.3M | 30 | 50 |
| 74 | AZL Aachen GmbH | Excellence in Lightweight Production | €7.0M | 30 | 50 |
| 75 | HPL Technologies GmbH | €7.0M | 30 | 50 |
| 76 | Test Industry - GiM | €7.0M | 30 | 50 |
| 77 | Sitemap - Souren Graphic- & Printservice | €7.0M | 30 | 50 |
| 78 | INOVAMED Gruppe | €6.7M | 125 | 50 |
| 79 | German Sherpa | Financial Consulting for Expats in Germany | €6.3M | 30 | 50 |
| 80 | Sozietät Libeaux Libeaux+Hensel PartGmbB | €6.3M | 30 | 50 |
| 81 | ADVIGO Winkler Steuerberater | €6.3M | 30 | 50 |
| 82 | Dr.-Ing. Mohamed Chouihi | €6.0M | 30 | 50 |
| 83 | Entwicklungsbüro für Fluidtechnik | €6.0M | 30 | 50 |
| 84 | Opel KOHL | Kohl automobile Vertriebs GmbH | €5.9M | 30 | 50 |
| 85 | TS Elino GmbH | €5.8M | 56 | 69 |
| 86 | ZENTIS Holding GmbH | €5.5M | -- | 69 |
| 87 | Bistum Aachen | €5.2M | 1,840 | 69 |
| 88 | tl;dv | €5.1M | 30 | 50 |
| 89 | SIGMASOFT by SIGMA Engineering GmbH | €5.1M | 30 | 50 |
| 90 | im.puls team | €5.0M | 30 | 50 |
| 91 | hotel-restaurant brunnenhof | €4.9M | 30 | 50 |
| 92 | tsv alemannia aachen 1900 e.v. | €4.9M | 30 | 50 |
| 93 | Minimal Mount | €3.8M | 5 | 50 |
| 94 | Lions Club Aachen Aix-la-Chapelle i.G. | €3.4M | 30 | 50 |
| 95 | Chair of Electronic Devices (ELD), RWTH Aachen University | €3.4M | 30 | 50 |
| 96 | RWTH Alumni | €3.4M | 30 | 50 |
| 97 | Fachschaft für Materialwissenschaft und Werkstofftechnik | €3.4M | 30 | 50 |
| 98 | CITE Project | €3.4M | 30 | 50 |
| 99 | Airline Entry Training | €3.4M | 30 | 50 |
| 100 | Fachschaft für Geographie und Wirtschaftsgeographie der RWTH Aachen | €3.4M | 30 | 50 |